The Sentinel

THE OFFICIAL BLOG OF THE SOCIETY FOR IMMUNOTHERAPY OF CANCER (SITC).

Showing posts with label ectopic lymphoid structures. Show all posts
Showing posts with label ectopic lymphoid structures. Show all posts

Thursday, January 18, 2018

Intratumoral Lymphoid Aggregates May be Tertiary Lymphoid Structures

by Aliyah Weinstein

It’s well established in the field of immuno-oncology that in nearly all cancers, a subset of patients presents with an immune infiltrate. In many of these tumors, the infiltrating immune cells appear to form aggregates that are especially noticeable at the tumor periphery. Indeed, when presenting my research on these aggregates at scientific meetings, I’ve often been approached by other scientists or clinicians who indicate that they’ve seen lymphoid aggregates in tumor tissue from their patients, but didn’t know to investigate them further. 

This brief overview may change some of those minds.