Hello JITC Readers,
Happy New Year and welcome to the first JITC Digest of 2023. We’re looking forward to the year ahead, and we’re excited for everything 2023 has in store for the journal. Be sure to check our special feature each month for the latest news. This month we’re extending a sincere and heartfelt thank you to the numerous volunteer reviewers who gave their time and expertise last year.
Our article highlight this month is evenly split between papers related to engineered T cell products for hematologic malignancies and checkpoint blockade for solid tumors. The research spans from preclinical characterization to long-term follow-up data from a pivotal phase III trial.
Katharina Baur and colleagues offer an intriguing case report on dasatinib for the management of CAR T cell therapy-associated toxicities. Anaïs Jiménez-Reinoso et al describe preclinical control of T cell leukemia with T cells engineered to secrete a bispecific antibody.
5-year follow-up data from Brian I Rini et al continue to demonstrate clinical benefit with ipilimumab in combination with nivolumab for the treatment of sarcomatoid renal cell carcinoma. Min Zheng offers analysis supporting a significant association between pre-treatment serum albumin levels and clinical benefit with checkpoint blockade across a variety of solid tumors.
With best wishes for 2023,
Pedro J. Romero, MD
Editor-in-Chief, Journal for ImmunoTherapy of Cancer
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