The Sentinel


Wednesday, November 16, 2022


Dear JITC Readers,

Welcome to the latest edition of the JITC Digest, arriving in your inboxes just a few days after SITC’s 2022 Annual Meeting and Pre-Conference Programs. It was wonderful to see everybody in person and interact with so many of you, the JITC readers, during our meet the editor sessions, the journal’s 10th anniversary reception, and out around Boston.

If you were not able to attend the concurrent session on Friday dedicated to JITC’s high-impact science, I encourage you catch up on the outstanding best paper award winners highlighted in this month’s special feature. Please also join me in extending heartfelt congratulations to the 2022 recipient of the Pedro J. Romero Service to JITC Award, Cornelis J.M. "Kees" Melief.

During her keynote address at SITC 2022, Padmanee Sharma described a model of iteration from clinical results to basic laboratory research that is then translated back to the clinic. JITC is proud to have supported this vital process over the past decade by publishing innovative science from across the basic science-translational-clinical spectrum, and we’re excited to help move our field forward for many more years in the future.

Our highlighted papers this month also span the basic science-translational-clinical spectrum, and include three original research articles and a case report.

Uncovering an underappreciated mechanism of immune dysfunction in the tumor microenvironment, Xia Liu and colleagues demonstrate that inhibition of DNA damage response signaling enhances the efficacy of PD-1 blockade by alleviating T cell senescence.

Enhanced T cell infiltration in both irradiated and non-irradiated lesions provides evidence for an abscopal effect with stereotactic body radiotherapy combined with pembrolizumab in a report from the phase II PEMBRO-RT trial from Lieke L van der Woude et al.

Xiaolu Yu and colleagues describe a novel PD-L1-directed nanobody conjugated to a Toll-like receptor 7 agonist that induced complete regressions in murine models of early, established, and immunologically cold tumors.

Finally, Niklas Kehl and colleagues describe the first comprehensive genomic and immune profiling of IgE multiple myeloma, finding an unprecedentedly high mutation burden in this orphan disease and identifying neoepitopes that elicit autoreactive T cell responses.

I hope everyone’s travels returning home from Boston were smooth!

Best regards,


Pedro J. Romero, MD
Editor-in-Chief, Journal for ImmunoTherapy of Cancer