The Sentinel

THE OFFICIAL BLOG OF THE SOCIETY FOR IMMUNOTHERAPY OF CANCER (SITC).

Wednesday, May 19, 2021

Letter From the Editor - May


Dear JITC Readers,

Welcome to the latest edition of the JITC Digest. Astute readers have likely noticed that this month’s digest is debuting a new feature. In addition to the usual programming—exciting new publications in JITC—the digest will now also highlight popular papers from the journal archive.
 
This month, we have four original research articles that offer novel insight on one of our field’s most challenging obstacles: resistance to therapy. Addressing immunotherapy resistance is a priority for the field as a whole, and the Society for Immunotherapy of Cancer is spearheading efforts toward developing uniform clinical definitions of resistance as well as support the basic and translational research in order to understand and overcome the mechanistic underpinnings.
 
Barbara Manzanares-Martin and colleagues reveal a surprising association between genomic heterozygosity for the killer-cell immunoglobin-like receptor and overcoming KRAS mutation-mediated resistance to cetuximab.
 
Disease that develops resistance to anti-PD-1 therapies is often highly challenging to treat, but results from two early phase trials in this month’s digest may offer patients new options. Brendan D Curti et al show safety and promising efficacy with the combination of a novel galectin antagonist and pembrolizumab for melanoma and head and neck cancer. Intratumoral injection of the oncolytic poliovirus PVSRIPO led to complete regressions even in uninjected lesions in some patients with melanoma in a phase I trial reported by Georgia M Beasley et al.
 
Finally, Michael W Knitz and colleagues provide deep mechanistic characterization of the interplay between dendritic cells and regulatory T cells that causes head and neck cancers to remain stubbornly immunologically cold after radioimmunotherapy.
 
Be sure to browse this month’s highlight of classic papers as well as the new original research—perhaps perspective from the archives may help spark novel insight into a new finding or vice versa.
 
Best regards,

Pedro J. Romero, MD
Editor-in-Chief, Journal for ImmunoTherapy of Cancer

To view the entire April 2021 JITC Digest, please click here

Monday, May 3, 2021

April/May President's Message: ARPA-H and Cancer Moonshot: A Chat with NCI Director Dr. Ned Sharpless

 Dear Colleagues,

As I am sure many of you saw, U.S. President Joe Biden recently announced as part of his administration’s budget plans to make considerable investment in research. The budget includes a request of $6.5 billion for the creation of a new health agency, the Advanced Research Projects Agency-Health (ARPA-H). According to many news reports, ARPA-H would reside within the National Institutes of Health and have a major focus on cancer, among other diseases.

To gain a better understanding of ARPA-H and a host of other topics involving the state of cancer research in the U.S., I recently hosted National Cancer Institute (NCI) Director Norman E. “Ned” Sharpless, MD for a fireside chat. I enjoyed my chat with Dr. Sharpless, which included discussion of the effect SARS-CoV-2 and the pandemic have had on the NCI, the role immunotherapy is playing in the advancement of cancer patient care in the U.S., the role the NCI can play in supporting promising areas of research and much more.

 

 

Watch the Entire SITC Fireside Chat

I’ve pulled a small portion of our chat, transcribed and inserted below, but I hope you have the time to listen to the full discussion, which you can view here.

Myself: As you know, SITC is an immunotherapy organization, and we appreciate you’ve spoken at our national meetings before, so thank you for that. Tell us about the National Cancer Institute, your views on immunotherapy and the importance of immunotherapy in the treatment of cancer.

Sharpless: Now I really talk about this fourth modality that we have – chemotherapy this kind of classical cytotoxic chemotherapy, surgery, radiation and this whole new toolbox of immunotherapy approaches. I think a really important thing for the NCI is how to support the clinical trials in the development of these agents, which is complicated and a lot of the paradigms have to change, measuring things like response and resistance to immunotherapy agents as some of the traditional approaches don’t apply as you know. But also I think we really have to continue to fund the basic science that supports the basic understanding of the immune system and its interaction with cancer, is still an area that I think is fascinating biology, and some of the new technologies, like single cell sequencing and new medicinal chemistry approaches, are really impactful in that area. It’s exciting to wed these new technologies to a really important problem like tumor immunology.

I also think there’s a role for the NCI for certain kinds of support of the clinical development of certain kinds of agents. The pharmaceutical industry does a really good job of combining PD-1 inhibitors with other agents. That’s a trial that Merck and others do very well, maybe not a high priority for the NCI unless it’s a really complicated trial or complicated agent, but where think there is a possible need for more support for the National Cancer Institute is around cellular immunotherapy trials, which is still quite challenging because of the manufacturing, regulatory and compliance issues, so I think there is a place where if the federal government can help de-risk these technologies a little more, by showing that they work, and particularly allowing trials to be multi-institutional. A single institution study is not nearly as convincing as something that the same CAR construct that can be done in multiple places with beneficial effect. So I think that’s an area where the federal government has a specific role to facilitate a very important kind of clinical research in immuno-oncology.

I think the suite of activities at the NCI now is very robust. As you know, the Cancer Moonshot which began in 2017, has a major focus on cancer immunology, both in adults and children, both in basic science and translational and clinical work. I think it’s really an established modality now and it’s important that the NCI work with groups like SITC to advance that mission.

Thank you very much to Dr. Sharpless for dedicating his time to speak about a range of important issues. I know our society looks forward to finding new and engaging ways our organization can collaborate with the NCI in the future. I also hope we get to see and hear from Dr. Sharpless in person during the 36th Annual Meeting & Pre-Conference Programs (SITC 2021), scheduled to take place Nov. 10–14 at the Walter E. Washington Convention Center in Washington, D.C., and virtually for those who cannot attend in person. I look forward to seeing the SITC family in D.C. this fall.

Sincerely,















Patrick Hwu, MD

SITC President