The Sentinel


Friday, April 17, 2020

JITC Letter from the Editor - April 2020

Dear JITC Readers,

Even as the COVID-19 pandemic continues to challenge almost all aspects of daily life, JITC remains unwavering in our commitment to publishing the very best that the immunotherapy field has to offer. Although SARS-CoV-2 is radically changing how we as a community care for our patients and conduct our research, you can count on JITC as a constant source for new findings and important insights from across the spectrum of immuno-oncology. 

This month, the JITC digest offers several papers that develop intriguing strategies to boost antitumor immune responses. Jahangir Ahmed and colleagues engineered a replication-competent oncolytic vaccinia virus that delivers IL-12 to the tumor microenvironment, prolonging survival and controlling lung metastases when administered as an adjuvant to surgical excision in mouse models. Modulation of the tumor microenvironment also synergized with checkpoint blockade in a paper by Lucas A. Horn et al., where combined inhibition of TGF-beta and IL-8 signaling attenuated epithelial to mesenchymal transition in models of both breast and lung cancer. Additionally, Yong Li and colleagues revealed a key role in signaling through the innate immune danger-recognition sensor RIG-I in the development of interferon resistance in melanoma tumor-regenerating cells, identifying STAT3 as a potential therapeutic target. 

Also this month, in a paper that will surely prove reassuring, Nicholas Bevins and colleagues rigorously analyzed the impact of different methods of calculating tumor mutational burden and found good correlation between approaches. 

Finally, be sure not to miss an outstanding review by Lorenzo Galluzzi et al. that delivers a thorough overview of immunologic cell death with detailed discussions of the biological mechanisms leading to the establishment of immunologic memory, the available assays to measure key phenomena, and the hurdles to overcome for translation into clinical benefit. 
Best regards,

Pedro J. Romero, MD
Editor-in-Chief, Journal for ImmunoTherapy of Cancer

To view the entire April 2020 JITC Digest, please click here

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