In the past decade, many advances in the field of
radio-immunotherapy have taken shape. There is undeniable therapeutic synergy
between radiation (XRT) and immunotherapy.
At the Welsh lab at MD AndersonCancer Center, we strive to find new approaches and effective combinations of
radiation with checkpoint inhibitors. In our quest, we found ourselves
re-thinking not only what the best combination is, but also what is the safest,
least toxic, and most translational treatment regimen.
This new frame of reference guided our lab into researching
the effects of low dose radiation on systemic immunotherapy outcomes. We
stumbled upon what we’ve now trademarked as the RadScopal™ treatment.
It all
started when Dr. Welsh routinely saw patients’ metastases respond to very low
dose radiation or the equivalent of background scatter received by lesions
outside the field of treatment. With these observations and careful
pre-clinical data, that RadScopal™ technique was born!
These exciting
findings have opened up a whole new avenue of radiation treatment expanding its
role from local therapy to systemic anti-tumor treatment.
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